Alcohol from 10,000 ft
Armin Moradi
2020-08-07
Epidemiology
- 90%
- 60-70%
- 40%+
- 10/5%
- 100000
Comorbidity
- Antisocial
- Mood
- Anxiety
- Suicide
Etiology
Absorption
- 10% stomach
- 90% small intestine
- 30-90min lag (usually 30-45mins)
- most rapid 15-30% alcohol
- too high of a concentration: pylorospasm -> N/V
Metabolism
- 90% liver oxidation -> constant rate ~10-34mg/dL/hr
- 10% kidney and lungs
- alcohol dehydrogenase: alcohol -> acetaldehyde (toxic)
- aldehyde dehydrogenase: acetaldehyde -> acetic acid
Effects
- fly high
- wings better than redbull
Effects 2.0
Effects 2.0 cont'd
- 0.05% -> thought, judgement, restraint are loosened
- 0.1% -> clumsy voluntary motor actions
- 0.1-0.15% -> legal intoxication
- 0.2% -> entire motor depression
- 0.3% -> confusion and stupor
- 0.4-0.5% -> coma
- >0.5% -> death due to respiratory depression, aspiration, etc
Dependence
- Alcohol use disorder: DSM-V
- So many types!
Withdrawal
- tremulousness
- psychotic and perceptual symptoms
- seizure
- delirium tremens
- irritability
- GI symptoms (N/V)
- sympathetic hyperactivity
Withdrawal treatment